uBriGene offers integrated CDMO services for plasmid and AAV manufacturing, with quality control and assurance, supporting diverse gene and cell therapy projects. Our off-the-shelf GMP AAV Rep/Cap plasmids will accelerate AAV production programs, bringing them to the clinic faster.
uBriGene's AAV Rep/Cap plasmids and AAV helper plasmids are qualified to deliver consistent quality and high yields for AAV GMP Manufacturing.
uBriGene has supported clients in obtaining IND clearance using AAV vectors produced with our GMP-grade plasmids, accelerating gene therapy development from preclinical studies to clinical manufacturing.
Manufactured and quality released under stringent GMP and regulatory standards.
Available in both R&D and GMP-grade AAV plasmids
Loyalty-free for use with uBriGene's GMP AAV production Services.
Activated FDA DMF on file #28890
The various Rep/Cap plasmids and helper plasmids have been tested for high quality and high yield in GMP AAV production.
We have assisted our clients in obtaining IND clearance with AAV produced using these AAV helper plasmids.
| Product Name | Catalog Number | Description | Grade | Price |
|---|---|---|---|---|
| YM-HELPER2.0 | 1302YM-HELPER2.0 | AAV Helper plasmid, providing adeno helper function for AAV packaging | ☑Research ☑GMP | |
| YM-RC1 | 1302YM-RC1 | AAV Rep-Cap1 plasmid, providing Rep/Cap for AAV1 serotype packaging | ☑Research ☑GMP | |
| YM-RC2 | 1302YM-RC2 | AAV Rep-Cap2 plasmid, providing Rep/Cap for AAV2 serotype packaging | ☑Research ☑GMP | |
| YM-RC3 | 1302YM-RC3 | AAV Rep-Cap3 plasmid, providing Rep/Cap for AAV3 serotype packaging | ☑Research ☑GMP | |
| YM-RC4 | 1302YM-RC4 | AAV Rep-Cap4 plasmid, providing Rep/Cap for AAV4 serotype packaging | ☑Research ☑GMP | |
| YM-RC5 | 1302YM-RC5 | AAV Rep-Cap5 plasmid, providing Rep/Cap for AAV5 serotype packaging | ☑Research ☑GMP | |
| YM-RC6 | 1302YM-RC6 | AAV Rep-Cap6 plasmid, providing Rep/Cap for AAV6 serotype packaging | ☑Research ☑GMP | |
| YM-RC7 | 1302YM-RC7 | AAV Rep-Cap7 plasmid, providing Rep/Cap for AAV7 serotype packaging | ☑Research ☑GMP | |
| YM-RC8 | 1302YM-RC8 | AAV Rep-Cap8 plasmid, providing Rep/Cap for AAV8 serotype packaging | ☑Research ☑GMP | |
| YM-RC9 | 1302YM-RC9 | AAV Rep-Cap9 plasmid, provide Rep-Cap for AAV9 packaging | ☑Research ☑GMP | |
| YM-RC10 | 1302YM-RC10 | AAV Rep-Cap10 plasmid, provide Rep-Cap for AAV10 packaging | ☑Research ☑GMP | Please Inquire |
| YM-RC11 | 1302YM-RC11 | AAV Rep-Cap11 plasmid, provide Rep-Cap for AAV11 packaging | ☑Research ☑GMP | |
| YM-RC12 | 1302YM-RC12 | AAV Rep-Cap12 plasmid, provide Rep-Cap for AAV12 packaging | ☑Research ☑GMP | |
| YM-RC13 | 1302YM-RC13 | AAV Rep-Cap13 plasmid, provide Rep-Cap for AAV13 packaging | ☑Research ☑GMP | |
| YM-RC myoAAV 1A | 1302YM-RCmyoAAV1A | AAV Rep-Cap myoAAV 1A plasmid, providing Rep/Cap for myoAAV 1A serotype packaging | For Service Only | |
| YM-7m8 | 1302YM-7m8 | AAV Rep-Cap 7m8 plasmid, providing Rep/Cap for AAV 7m8 serotype packaging | For Service Only | |
| AAV2/Anc80L65AAP | 1302AAV2/Anc80L65AAP | AAV Rep-Cap Anc80L65AAP plasmid, providing Rep/Cap for AAV Anc80L65 serotype packaging | For Service Only | |
| RC-ANC80 | 1302YM-ANC80 | AAV Rep-Cap Anc80 plasmid, providing Rep/Cap for AAV Anc80 serotype packaging | For Service Only | |
| pscAV-CMV-eGFP | 1302pscAV-CMV-GFP | scAAV transfer plasmid containing CMV driven eGFP | ☑Research ☐GMP | |
| YM-AAV-GFP | 1302YM-AAV-GFP | AAV transfer plasmid containing CAG driven eGFP | ☑Research ☐GMP |
Off the shelf AAV Plasmids
GMP pHelper & pRep/Cap plasmids
Active FDA DMF #28890
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Automated closed-system technology for manufacturing ensures sterility with functionally closed disposables, minimizes operator errors through pre-programmed steps, and enhances consistency by reducing variability. It also reduces technician hands-on time and lowers production costs.
Extensive plasmid production experience
100+ GMP plasmid projects annually
The AAV packaging productivity of our helper and various Rep/Cap plasmids using transient transfection methods. AAV particles were purified using chromatography
| Test Item | Method | |
|---|---|---|
| Appearance | Visual inspection | |
| pH | pH measurement | |
| Concentration | UV, Spectrophotometry | |
| Identity | Restriction analysis | Gel electrophoresis |
| Target sequence analysis* | Sanger sequencing | |
| Purity | A260/A280 | UV, Spectrophotometry |
| Supercoiled plasmid ratio | HPLC | |
| Residuals | Residual E. Coli DNA | qPCR |
| Residual E. Coli RNA | Gel electrophoresis/HPLC | |
| Residual E. Coli protein | ELISA | |
| Safety | Endotoxin | Gel-clot assay |
| Sterility | Membrane filtration method | |
Explore uBriGene’s robust GMP plasmid manufacturing process and testing capabilities.
Discover our AAV manufacturing capabilities, scalable processes, testing platform.
Learn more about how uBriGene supported our client to get AAV IND clearance in just 9 months.
Learn more about our CAR-T CDMO manufacturing for high-quality therapies.
We offer a wide range of AAV serotype Rep/Cap plasmids to support various gene therapy applications, including Rep/Cap1, Rep/Cap2, Rep/Cap3, Rep/Cap4, Rep/Cap5, Rep/Cap6, Rep/Cap7, Rep/Cap8, and Rep/Cap9, all the way to AAV13. If you need custom Rep/Cap and GOI, our expert plasmid production team can provide plasmid process development and GMP manufacturing.
Our plasmids are manufactured to the highest AAV GMP standards, ensuring consistent quality and performance in large-scale AAV production for both preclinical and clinical stages.
Yes, our AAV helper plasmid is suitable for both preclinical and clinical development, offering seamless transition to AAV GMP manufacturing.
We implement rigorous in-house QC testing, including identity, purity, and safety assays, to ensure the highest quality and performance of our plasmids.
Yes, our AAV Rep/Cap plasmids and AAV helper plasmid have active FDA DMF #28890, significantly reducing the regulatory review process. Many of our clients have successfully achieved IND clearance using uBriGene's AAV Rep/Cap plasmids and AAV helper plasmid.
Our AAV Rep/Cap plasmid and AAV helper plasmid have been tested for high yield and quality, consistently delivering robust AAV production with minimal impurities. The AAV yield varies with different AAV serotypes, ranging from E13 to E14 VG/mL.
Yes, all of our off-the-shelf AAV Rep/Cap plasmids and AAV helper plasmid are royalty-free, offering cost-effective solutions for your gene therapy programs.
Our off-the-shelf AAV plasmids are readily available, and we typically ship them within 1–2 weeks after order confirmation.
Our AAV Rep/Cap plasmids and AAV helper plasmid are fully scalable, supporting small to large-scale manufacturing to meet the needs of both preclinical and commercial production.
Extensive expertise with a track record of successfully releasing over 60 GMP batches of AAV.
GMP grade AAV helper plasmid and AAV Rep/Cap plasmids
Active FDA DMF #28890
Proven - AAV produced using the AAV helper plasmid received IND clearance
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Ask the plasmid DNA expert! With over 300 GMP batches in our track record and our cost-effective platform technology, we can help accelerate your clinical programs.
