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LVV Packaging
Wildly used in gene therapy applications such as CAR-T therapy, Lentivirus is one of the most efficient methods for gene delivery due to its large packaging capacity and its ability to infect non-dividing cells and integrate into the host genome. uBriGene offers LVV packaging service with customizable scales and grades. Relative downstream LVV services are also available.
uBriGene’s LVV Packaging Workflow
Comparison with Other Viruses
Characteristic | AAV | Adenovirus | Lentivirus |
|---|---|---|---|
Origin | AAV-2 | Adenovirus type 5 | HIV-1 |
Genome | 4.8 kb (ssDNA) | 36 kb (dsDNA) | 9 kb (ssRNA) |
Packaging capacity | 4.7 kb | 7.5 kb | 9 kb |
Infection | Most dividing and non-dividing cells | Most dividing and non-dividing cells | Most dividing and non-dividing cells |
Transduction efficiency | Moderate | High | Moderate |
Integration | Non-integrating | Non-integrating | Integrating |
Expression | Transient or stable | Transient | Stable |
Immunogenicity | Very low | High | Low |
Biosafety | BSL-1 | BSL-2 | BSL-2 |
Advantages | High transduction efficiency, Wide range of applications, Stable hereditary | High transduction efficiency, Large capacity, High titer | Low immunogenicity, High safety, High specificity |
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